Peer-Reviewed Articles

1.       Carey A, Parodi-Rullan R, Vazquez-Torres R, Canepa E, Fossati S. Homocysteine potentiates amyloid β- induced death receptor 4- and 5-mediated cerebral endothelial cell apoptosis, blood-brain barrier dysfunction and angiogenic impairment. Aging Cell. 2024 Feb 15:e14106. DOI: 10.1111/acel.14106.

2.       Anzovino A, Canepa E, Alves M, Lemon NL, Carare RO, Fossati S. Amyloid Beta Oligomers Activate Death Receptors and Mitochondria-Mediated Apoptotic Pathways in Cerebral Vascular Smooth Muscle Cells; Protective Effects of Carbonic Anhydrase Inhibitors. Cells. 2023; 12(24):2840. DOI: 10.3390/cells12242840

3.       Canepa E, Parodi-Rullan R, Vazquez-Torres R, Gamallo-Lana B, Guzman-Hernandez R, Lemon NL, Angiulli F, Debure L, Ilies MA, Østergaard L, Wisniewski T, Gutiérrez-Jiménez E, Mar AC, Fossati S. FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness. Alzheimers Dement. 2023 Apr 26. DOI: 10.1002/alz.13063. Epub ahead of print. PMID: 37186121. 

4.       Carey A, Fossati S. Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers. Alzheimers Dement. 2023 Feb;19(2):671-695. DOI: 10.1002/alz.12871. Epub 2022 Nov 19. PMID: 36401868; PMCID: PMC9931659.

5.       Jang S, Chapa-Dubocq XR, Fossati S, Javadov S. Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria. Front Physiol. 2021 Dec 7;12:773839. DOI: 10.3389/fphys.2021.773839. PMID: 34950052; PMCID: PMC8688924.

6.       Lemon N, Canepa E, Ilies MA, Fossati S. Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer's Disease and Stroke. Front Aging Neurosci. 2021 Nov 16;13:772278. DOI: 10.3389/fnagi.2021.772278. PMID: 34867298; PMCID: PMC8635164.

7.       Parodi-Rullán RM, Javadov S, Fossati S. Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Cells. 2021 Oct 27;10(11):2903. DOI: 10.3390/cells10112903. PMID: 34831125; PMCID: PMC8616424.

8.       Wisniewski T, Fossati S. Reader Response: Blood Biomarkers of Traumatic Brain Injury and Cognitive Impairment in Older Veterans. Neurology. 2021 Jul 13;97(2):101. DOI: 10.1212/WNL.0000000000012255. PMID: 34253655; PMCID: PMC8589288.

9.       Jaime Ramos‐Cejudo, Afia Genfi, Duna Abu‐Amara, Ludovic Debure, Meng Qian, Eugene Laska, Carole Siegel, Nicholas Milton, Jennifer Newman, Esther Blessing, Meng Li, Amit Etkin, Charles R. Marmar, Fossati S, CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans. Psychiatric Research and Clinical Practice 2021. Jun 2021 https://doi.org/10.1176/appi.prcp.20210017

10.   Canepa E, Fossati S. Impact of Tau on Neurovascular Pathology in Alzheimer's Disease. Front Neurol. 2021 Jan 7;11:573324. DOI: 10.3389/fneur.2020.573324. PMID: 33488493; PMCID: PMC7817626.

11.   Canepa E, Vazquez‐Torres R, Debure L, Fossati S. Carbonic anhydrase inhibition ameliorates Aβ‐induced neurovascular dysfunction in vivo: Molecular and cell biology/vascular factors. Alzheimer's & Dementia. 2020 Dec; 16:e044221.https://doi.org/10.1002/alz.044221

12.   Parodi‐Rullan RM, Sone JY, Fossati S. Vascular dysfunction in CAA in the presence of cardiovascular risk factors: The role of the mitochondria and therapeutic approaches: Molecular and cell biology/mitochondrial function/energetics. Alzheimer's & Dementia. 2020 Dec;16:e043944. https://doi.org/10.1002/alz.043944

13.   Cantero JL, Atienza M, Ramos-Cejudo J, Fossati S, Wisniewski T, Osorio RS. Plasma tau predicts cerebral vulnerability in aging. Aging (Albany NY). 2020 Nov 4;12(21):21004-21022. DOI: 10.18632/aging.104057. Epub 2020 Nov 4. PubMed PMID: 33147571; PubMed Central PMCID: PMC7695405.

14.   Parodi R., Ghiso J., Cabrera E., Rostagno A., and Fossati S. Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis. Aging Cell. 2020 Nov;19(11):e13258. https://doi.org/10.1111/acel.13258. Epub 2020 Nov 6. PMID: 33155752

15.    Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, Hawkes CA, Koronyo-Hamaoui M, Hainsworth AH, Holtzman D, Ihara M, Jefferson A, Kalaria RN, Kipps CM, Kanninen KM, Leinonen V, McLaurin J, Miners S, Malm T, Nicoll JAR, Piazza F, Paul G, Rich SM, Saito S, Shih A, Scholtzova H, Snyder H, Snyder P, Thormodsson FR, van Veluw SJ, Weller RO, Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimers Dement (Amst). 2020 Aug 3;12(1):e12053. DOI: 10.1002/dad2.12053. PMID: 32775596; PMCID: PMC7396859.

16.   Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A,… Fossati S (as part of the PTSD System Biology Consortium), Hammamieh R, Doyle FJ 3rd, Jett M, Marmar CR, Mellon SH, Wolkowitz OM. Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jul;5(7):678-687. DOI: 10.1016/j.bpsc.2020.03.007. Epub 2020 Mar 31. Erratum in: Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jun 23;: PMID: 32439402.

17.   Giannoni P, Fossati S, Marcello E, Claeysen S. Editorial: Identification of Multiple Targets in the Fight Against Alzheimer's Disease. Front Aging Neurosci. 2020 Jun 16;12:169. DOI: 10.3389/fnagi.2020.00169. PMID: 32612524; PMCID: PMC7308806.

18.   Provensi G, Carta F, Nocentini A, Supuran CT, Casamenti F, Passani MB, Fossati S. A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease. Int J Mol Sci. 2019 Sep 24;20(19):4724. DOI: 10.3390/ijms20194724. PMID: 31554165; PMCID: PMC6801497.

19.  Dean K, Hammamieh R, Mellon S, Abu-Amara D, Fossati S (as part of the PTSD System Biology Consortium) and Marmar C. Multi-omic biomarker identification and validation for diagnosing warzone-related Post-Traumatic Stress Disorder. Mol Psychiatry. 2019 Sep 10. https://doi.org/10.1038/s41380-019-0496-z . [Epub ahead of print] PMID: 31501510

20.   Parodi-Rullán R, Sone JY, Fossati S. Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease. J Alzheimers Dis. 2019 Jul 8. DOI: 10.3233/JAD-190357. [Epub ahead of print] PMID: 31306129

21.   Fossati S, Ramos Cejudo J, Debure L, Pirraglia E, Sone JY, Li Y, Chen J, Butler T, Zetterberg H, Blennow K, de Leon MJ. Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease. Alzheimers Dement (Amst). 2019 Jun 28;11:483-492. DOI: 10.1016/j.dadm.2019.05.001. PMID: 31334328; PMCID: PMC6624242.

22.    Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimer’s and Dementia (NY). 2019 Apr 9;5:107-117. DOI: 10.1016/j.trci.2019.02.001. eCollection 2019. Review. PMID: 31011621

23.   A Etkin, G A. Fonzo, W Wu, J Huemer, B Patenaude, P E. Vértes, J Richiardi, MS. Goodkind, CJ. Keller, J Ramos Cejudo, YV. Zaiko, KK. Peng, E Shpigel, P Longwell, RT. Toll, A Thompson, S Zack, B Gonzalez, R Edelstein, J Chen, I Akingbade, E Weiss, R Hart, S Mann, K Durkin, S Baete, F Boada, A Genfi, J Autea, J Newman, D J. Oathes, S E. Lindley, D Abu-Amara, B A. Arnow, N Crossley, J Hallmayer, Fossati S, B O. Rothbaum, CR. Marmar, ET. Bullmore, R O’Hara. Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder. Science Translational Medicine, 2019 Apr 3;11(486). pii: eaal3236. DOI: 10.1126/scitranslmed.aal3236.

24.   Fossati S, Cejudo JR, Genfi A, Abu-Amara D, Marmar C. T16. Discovery of Novel Blood Biomarkers for PTSD and TBI. Biological Psychiatry. 2018 May 1;83(9):S1345. DOI:https://doi.org/10.1016/j.biopsych.2018.02.352

25.    Solesio ME, Peixoto PM, Debure L, Madamba SM, de Leon MJ, Wisniewski T, Pavlov EV, Fossati S. Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity. Aging Cell. 2018 Aug;17(4):e12787. DOI: 10.1111/acel.12787. Epub 2018 Jun 5. PMID: 29873184; PMCID: PMC6052473.

26.   Ramos-Cejudo J, Wisniewski T, Marmar C, Zetterberg H, Blennow K, de Leon MJ, Fossati S. Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link. EBioMedicine. 2018 Feb;28:21-30. DOI: 10.1016/j.ebiom.2018.01.021. Epub 2018 Jan 31. PMID: 29396300; PMCID: PMC5835563.

27.   de Leon MJ, Pirraglia E, Osorio RS, Glodzik L, Saint-Louis L, Kim HJ, Fortea J, Fossati S, Laska E, Siegel C, Butler T, Li Y, Rusinek H, Zetterberg H, Blennow K; Alzheimer’s Disease Neuroimaging Initiative; National Alzheimer’s Coordinating Center. The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PLoS One. 2018 Feb 7;13(2):e0191240. DOI: 10.1371/journal.pone.0191240. PMID: 29415068; PMCID: PMC5802432.

28.   Fossati S, Cejudo JR, Debure L, et al. Differential value of plasma tau as a biomarker for Alzheimer's disease and chronic traumatic brain injury. Alzheimer’s and Dementia. 2017 Jul;13(7):4-133. DOI: https://doi.org/10.1016/j.jalz.2017.06.1999. 

29.   de Leon MJ, Li Y, Okamura N, Tsui WH, Saint-Louis LA, Glodzik L, Osorio RS, Fortea J, Butler T, Pirraglia E, Fossati S, Kim HJ, Carare RO, Nedergaard M, Benveniste H, Rusinek H. Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET. J Nucl Med. 2017 Sep;58(9):1471-1476. DOI: 10.2967/jnumed.116.187211. Epub 2017 Mar 16. PMID: 28302766; PMCID: PMC5577629.

30.   Fossati S, Solesio ME, Pavlov E, Wisniewski T. P2‐099: Carbonic Anhydrase is a Crucial Target for Prevention of Mitochondrial Pathology in Alzheimer’s Models. Alzheimer's & Dementia. 2016 Jul;12:P650.DOI: https://doi.org/10.1016/j.jalz.2016.06.1261

31.   Fossati S. Commentary: The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.World Biomedical Frontiers ISSN: 2328-0166, March 2016. 

32.   Fossati S, Giannoni P, Solesio ME, Cocklin SL, Cabrera E, Ghiso J, Rostagno A. The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. Neurobiol Dis. 2016 Feb;86:29-40. DOI: 10.1016/j.nbd.2015.11.006. Epub 2015 Nov 12. PMID: 26581638; PMCID: PMC4713307.

33.   J Spiegel, E Pirraglia, Y Li, W Tsui, L Glodzik, R Osorio, L A. Saint Louis, C Randall, T Butler, J Xu, R P Zinkowski, H Zetterberg, J Fortea, S Fossati, T Wisniewski, P Davies, K Blennow, M J de Leon. Greater specificity for CSF P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer’s. J Alzheimers Dis. 2015 Sep 28;49(1):93-100. DOI: 10.3233/JAD-150167

34.   Fossati S, Giannoni P,  Solesio M, Cocklin S, Cabrera E,  Ghiso J, Rostagno A. Methazolamide protects neuronal and glial cells from amyloid toxicity in vitro and in vivo via mitochondria-mediated mechanisms. Alzheimer's & Dementia 2015 11(7):P860-P861 (# 1923902). https://doi.org/10.1016/j.jalz.2015.08.037

35.   Fossati, S; Giannoni, P; Solesio, M; Del, Mar Hernandez M; Ghiso, J; Rostagno, A. Death receptors, and mitochondria as crucial targets for drug discovery in cerebral amyloid angiopathy. 2015-04-10; 0039-2499, Stroke - id: 1522242, year: 2015.

36.    Ghiso J; Fossati S; Rostagno A. Amyloidosis associated with cerebral amyloid angiopathy: Cell signaling pathways elicited in cerebral endothelial cells, 2014-04-09; 1387-2877, Journal of Alzheimer's Disease - id: 871452, year: 2014. DOI: 10.3233/JAD-140027

37.   Todd K, Fossati S, Ghiso J, Rostagno A. Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2457-67. DOI: 10.1016/j.bbadis.2014.09.010. Epub 2014 Sep 28. PMID: 25261792; PMCID: PMC4454292.

38.    S Fossati, P Giannoni, M Hernandez-Guillamon, J Montaner, J Ghiso, A. Rostagno. Mitochondria and death receptors: Key targets for amyloid toxicity in the cerebral vasculature. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014-10 (4), P191. DOI: 10.1016/j.jalz.2014.04.222

39.    Fossati S, Todd K, Sotolongo K, Ghiso J, Rostagno A. Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation. Biochem J. 2013 Dec 15;456(3):347-60. DOI: 10.1042/BJ20130652. PMID: 24028142; PMCID: PMC4467552.

40.   Fossati S; Ghiso J; Rostagno A. Amyloid beta oligomers trigger death receptors-mediated apoptosis in cerebral endothelial cells. FASEB journal. 2012:26. ISSN: 0892-6638 https://doi.org/10.1096/fasebj.26.1_supplement.752.8

41.    Fossati S, Ghiso J, Rostagno A. TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ. Cell Death Dis. 2012 Jun 14;3(6):e321. DOI: 10.1038/cddis.2012.55. PMID: 22695614; PMCID: PMC3388229.

42.   Fossati S, Ghiso J, Rostagno A. Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells. Neurodegener Dis. 2012;10(1-4):324-8. DOI: 10.1159/000332821. Epub 2011 Dec 7. PMID: 22156599; PMCID: PMC3363348.

43.   Rostagno A, Fossati S, Ghiso J. Fibrillogenesis and toxicity of Iowa-Aβ amyloid is primarily driven by the D23 mutation. Alzheimer’s & Dementia, 2010; 6: S242. DOI10.1016/j.jalz.2010.05.788

44.   Fossati S, Ghiso J, Rostagno A. Molecular analysis of apoptotic pathways induced by amyloid-β variants in cerebral vascular cells. Alzheimer’s & Dementia, 2010; 6: S376-S377. https://doi.org/10.1016/j.jalz.2010.05.1264

45.   Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem. 2010 Aug 27;285(35):27144-27158. DOI: 10.1074/jbc.M110.135228. Epub 2010 Jun 24. PMID: 20576603; PMCID: PMC2930713.

46.   Fossati S, Cam J, Meyerson J, et al. Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls. FASEB J. 2010;24(1):229-241. doi: 10.1096/fj.09-139584

47.   Faraco G, Pittelli M, Cavone L, Fossati S, Porcu M, Mascagni P, Fossati G, Moroni F, Chiarugi A. Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol Dis. 2009 Nov;36(2):269-79. DOI: 10.1016/j.nbd.2009.07.019. Epub 2009 Jul 25. PMID: 19635561.

48.   Viana RJ, Nunes AF, Castro RE, Ramalho RM, Meyerson J, Fossati S, Ghiso J, Rostagno A, Rodrigues CM. Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. Cell Mol Life Sci. 2009 Mar;66(6):1094-104. DOI: 10.1007/s00018-009-8746-x. PMID: 19189048; PMCID: PMC2760857.

49.   Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and Arctic mutant peptides of beta-amyloid (1-40) differentially affect the FGF-2 pathway in brain endothelium. Exp Cell Res. 2009 Feb 1;315(3):385-95. DOI: 10.1016/j.yexcr.2008.11.002. Epub 2008 Nov 19. PMID: 19061884; PMCID: PMC2764262.

50.   Faraco G, Fossati S, Bianchi ME, Patrone M, Pedrazzi M, Sparatore B, Moroni F, Chiarugi A. High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. J Neurochem. 2007 Oct;103(2):590-603. DOI: 10.1111/j.1471-4159.2007.04788.x. Epub 2007 Jul 31. PMID: 17666052.

51.   Aldinucci A, Gerlini G, Fossati S, Cipriani G, Ballerini C, Biagioli T, Pimpinelli N, Borgognoni L, Massacesi L, Moroni F, Chiarugi A. A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J Immunol. 2007 Jul 1;179(1):305-12. DOI: 10.4049/jimmunol.179.1.305. PMID: 17579050.

52.   Fossati S, Chiarugi A. Relevance of High‐Mobility Group Protein Box 1 to Neurodegeneration. International review of neurobiology. 2007 Jan 1;82:13748. https://doi.org/10.1016/S0074-7742(07)82007-1.

53.   Porcu M, Guarna F, Formentini L, Faraco G, Fossati S, Mencucci R, Rapizzi E, Menchini U, Moroni F, Chiarugi A. Carboxymethyl beta-glucan binds to corneal epithelial cells and increases cell adhesion to laminin and resistance to oxidative stress. Cornea. 2007 Jan;26(1):73-9. DOI: 10.1097/ICO.0b013e31802e3872. PMID: 17198017.

54.   Fossati S, Cipriani G, Moroni F, Chiarugi A. Neither energy collapse nor transcription underlies in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activation. Neurochem Int. 2007 Jan;50(1):203-10. DOI: 10.1016/j.neuint.2006.08.009. Epub 2006 Oct 18. PMID: 17052800.

55.   Fossati S, Formentini L, Wang ZQ, Moroni F, Chiarugi A. Poly(ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblasts. Biochem Cell Biol. 2006 Oct;84(5):703-12. DOI: 10.1139/o06-083. PMID: 17167533.

56.   Cozzi A, Cipriani G, Fossati S, Faraco G, Formentini L, Min W, Cortes U, Wang ZQ, Moroni F, Chiarugi A. Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. J Cereb Blood Flow Metab. 2006 May;26(5):684-95. DOI: 10.1038/sj.jcbfm.9600222. PMID: 16177811.

57.   Rapizzi E, Fossati S, Moroni F, Chiarugi A. Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. Mol Pharmacol. 2004 Oct;66(4):890-8. DOI: 10.1124/mol.104.000968. Epub 2004 Jun 30. PMID: 15229295.